Tsis ntev los no, cov kws tshawb fawb los ntawm European Institute of Oncology tau tshawb pom tias metformin thiab kev yoo mov ua rau muaj kev sib koom ua ke los txo cov qog loj hlob hauv cov nas.
Metformin ua ke nrog Fasting Synergistically inhibits qog nqaij hlav
Kev tshawb nrhiav kev siv tshuab ntxiv tau qhia tias metformin thiab nrawm nrawm nrawm ntawm cov qog loj hlob ntawm PP2A-GSK3 -MCL-1 txoj kev taw qhia; txoj kev tshawb no tau luam tawm nyob rau hauvMob qog noj ntshav.
Hauv qhov kev tshawb fawb no, cov kws tshawb fawb tau sib koom ua ke nrog kev yoo mov nrog metformin txhawm rau txheeb xyuas cov peev txheej kho mob ntawm qhov kev sib xyaw ua ke tiv thaiv qog nqaij hlav thiab nthuav tawm nws cov txheej txheem molecular hauv qab.
Tib neeg cov kab mob qog noj ntshav tau muab cog rau hauv cov nas sim, uas tau muab faib ua tsib pawg. Ob pawg tau muab kev txwv tsis pub tshaj tawm libitum nkag mus rau zaub mov, thaum lwm tus peb tau ua 24-teev kev yoo mov tsis sib xws. Cov nas nyob rau hauv cov txheej txheem pub mis lossis yoo mov noj tau muab tshuaj metformin lossis placebo raws li.
Thaum lub sij hawm yoo mov, cov nas tau pom qhov poob qis hauv cov ntshav qabzib nrog rau qhov hnyav me me (12 grams, hloov tsis pom zoo). Txawm hais tias metformin nws tus kheej txo qis cov ntshav qabzib hauv lub hom phiaj rau hyperglycemia, tsis muaj kev pheej hmoo ntawm kev mob ntshav qab zib ntau ntau hauv cov nas yoo mov tau txais cov tshuaj.
Tshwj xeeb tshaj yog, cov qog nqaij hlav loj hlob tau ruaj khov hauv cov pab pawg tau txais kev yoo mov thiab kev kho metformin. Tom qab kev yoo mov raug txiav thiab kev noj zaub mov tsis tu ncua, cov ntshav qabzib thiab lub cev qhov hnyav ntawm cov nas hypoglycemic rov qab los rau hauv lub hauv paus, txo kev txhawj xeeb txog kev tsis zoo ntawm kev txwv caloric.
Kev yoo mov ua rau muaj kev hloov pauv ntawm lub cev ntau dua li tsuas yog hypoglycemia; circulating theem ntawm kev loj hlob yam tseem ceeb thiab cov as-ham kuj poob qis heev nyob rau hauv cov as-ham deprivation.
Txhawm rau txheeb xyuas cov ntsiab lus zoo tshaj plaws hauv metabolic uas muaj peev xwm ua kom muaj zog metformin los tiv thaiv- qog nqaij hlav, cov neeg tshawb xyuas kab mob qog nqaij hlav qog noj ntshav hauv tib neeg thiab HeLa hlwb nyob rau hauv qis- qabzib thiab qis-amino- cov kua qaub, ua raws li kev kho mob nrog metformin lossis placebo tswj. Cov qog hlwb tau pom tias muaj kev nkag siab zoo rau metformin tshwj xeeb hauv qhov qis -glucose ib puag ncig, lees paub tias kev tiv thaiv kev tiv thaiv - mob qog noj ntshav yuav tsum muaj kev sib xyaw ua ke ntawm hypoglycemic tej yam kev mob thiab metformin- tsis yog ib leeg ib leeg txaus.
Txawm li cas los xij, cov kws tshawb fawb tau sau tseg tias txawm hais tias qhov poob phaus tau pom hauv metformin- kho cov nas yoo mov tsawg, kev txwv caloric yog keeb kwm cuam tshuam nrog kev pheej hmoo ntawm kev nyab xeeb. Muab qhov sib txawv ntawm qhov sib txawv ntawm cov rog thiab lub cev muaj pes tsawg leeg ntawm cov nas thiab tib neeg, kev sim tshuaj ntxiv yuav tsum tau ua kom paub tseeb tias kev nyab xeeb ntawm qis - qabzib - metformin kev sib xyaw ua ke hauv cov neeg mob qog noj ntshav.
Kev txwv caloric raws li kev tiv thaiv- cov tswv yim qog nqaij hlav tsis yog lub tswv yim tshiab. Kev siv hluav taws xob tsis txaus txo qis kev ua haujlwm ntawm cov metabolism hauv lub cev, txo cov qog nqaij hlav, thiab txhim kho kev siv tshuaj khomob.
Cov kev tshawb fawb ua ntej tau ua pov thawj tias nruj tswj hwm kev yoo mov tsis tu ncua tiv thaiv cov neeg mob los ntawm kev siv tshuaj khomob -induced toxicities yam tsis ua rau poob phaus ntau dhau los ntawm kev txwv caloric hnyav. Kev yoo mov tsis tu ncua yog li ntawd sawv cev rau lub tswv yim zoo los txhim kho kev tiv thaiv - cov txiaj ntsig kho mob qog noj ntshav.
Editorial commentaries muaj tus yam ntxwvmetforminraws li tus neeg sawv cev tshiab muaj zog hauv oncology. Kev khav theeb muaj txiaj ntsig zoo rau kev nyab xeeb, tam sim no tab tom tshawb nrhiav raws li kev kho mob qog noj ntshav thiab rau kev siv combinatorial nrog rau lwm cov tshuaj tiv thaiv -neoplastic regimens.
Cov tshuaj tiv thaiv -Tumor Therapeutic Potential ntawm Metformin
Lub synergistic anti- qog nyhuv ntawmmetforminthiab kev yoo mov tsis yog thawj qhov piv txwv ntawm metformin ua haujlwm hauv kev hais kwv txhiaj nrog lwm cov kev cuam tshuam los tawm tsam cov kab mob phem.
Ib txoj kev tshawb fawb yav dhau los coj los ntawm Dr. Marsha Rich Rosner pab pawg hauv University of Chicago tau tshaj tawm tias kev sib xyaw ntawm metformin thiab panhematin, uas tsim cov tshuaj classic, ua rau muaj kev kho mob rau triple -mob qog noj ntshav tsis zoo- kab mob ua rau muaj kev hem thawj rau poj niam txoj kev noj qab haus huv.
Heme yog lub hauv paus tseem ceeb ntawm hemoglobin, uas muaj ntau hauv cov qe ntshav. Panhematin, ib qho heme-raws li kws tshuaj, tau txais kev tso cai ntev ntev rau kev tswj hwm ntawm heme biosynthesis deficiency disorders.
Cov ntaub ntawv pov thawj qhia tau hais tias qhov kev kho mob no yuav muaj txiaj ntsig zoo rau ntau yam ntawm cov kab mob malignancies, suav nrog mob qog noj ntshav, mob raum, mob qog noj ntshav, mob qog noj ntshav, prostate cancer, thiab mob myeloid leukemia, nrog rau cov kev tshawb pom uas cuam tshuam tau luam tawm nyob rau saum -tier phau ntawv journalXwm.
Tsis tas li ntawd, ntau qhov kev tshawb fawb txog kev kis kab mob uas tau ua nyob rau xyoo tas los no qhia tias metformin muaj cov qog nqaij hlav - tiv thaiv thiab kho cov khoom.
Kev loj hlob ntawm lub cev ntawm kev tshawb fawb txhawb nqa metformin lub peev xwm los tiv thaiv kev mob ntsws cancer thiab txhim kho kev soj ntsuam kuaj mob rau cov neeg mob qog noj ntshav.
Tshaj li cov lus hais los saum toj no los tiv thaiv- daim ntawv thov mob qog noj ntshav, metformin, lub sijhawm- hwm tus neeg sawv cev ntawm qhov ncauj hypoglycemic, tseem ua rau cov txiaj ntsig kho tsis tau zoo rau tib neeg kev noj qab haus huv.
