Abiraterone acetate hmoov yog ib qho kev xaiv zoo heev, irreversible CYP17 enzyme inhibitor, thiab CYP17 yog ib qho tseem ceeb enzyme tseem ceeb rau androgen biosynthesis. Los ntawm inhibiting cov enzyme tseem ceeb koom nrog hauv androgen synthesis, abiraterone acetate txo cov qib androgen.
1. Originator Drug: Ntiaj teb no xub pib thiab kev lag luam nkag mus hauv Suav teb
Kev ua lag luam thoob ntiaj tebTsim los ntawm Johnson & Johnson, abiraterone acetate tau pom zoo los ntawm US FDA nyob rau lub Plaub Hlis 2011 rau kev kho mob ntawm metastatic castration - resistant prostate cancer (mCRPC), tsim nws tus kheej ua tus qauv rau kev kho mob qog noj ntshav thoob ntiaj teb.
Suav lag luamNws tau pom zoo nyob rau hauv Tuam Tshoj thaum lub Tsib Hlis 2015 thiab tau tshaj tawm thaum ntxov 2016. Thaum pib lub sijhawm pib, tus nqi kho mob txhua hli tau tshaj RMB 16,000, nrog tus nqi txhua xyoo siab txog RMB 200,000, tus nqi tsuas yog rau cov neeg mob tsawg xwb.
2. Cov Generics hauv tsev: batch kev pom zoo thiab kev sib tw ua lag luam ntxiv
Raws li lub Cuaj Hlis 2023, tag nrho ntawm 11 lub tuam txhab tshuaj hauv tsev tau txais kev tso npe tso npe rau cov ntsiav tshuaj abiraterone acetate, thiab lwm 3 lub tuam txhab tau nyob rau theem kev tshawb fawb soj ntsuam.Cov generics no tau pom zoo raws li Chav Kawm.
4 Cov Tshuaj Tshiab (Kev Ntsuam Xyuas Kom Zoo), nrog kev ua tau zoo thiab kho tau zoo sib npaug rau cov khoom tsim khoom.
3. R&D Pipeline Hloov Kho: Kev Ua Tau Zoo Tshaj Plaws hauv Kev Siv Daim Ntawv Khomob thiab Kev Txhim Kho Lub Zog
Dosage Form ExplorationNtawm 3 lub lag luam nyob rau hauv txoj kev loj hlob, 2 tab tom tsim cov tshuaj ntsiav tshuaj, aiming los txhim kho cov neeg mob cov tshuaj yooj yim thiab txo cov nqi tsim khoom.
Hloov Tshuaj TshiabHengrui Tshuaj's nanocrystal formulation tau launched. Cov tuam txhab tom qab tuaj yeem tsom mus rau R&D ntawm kev txhawb nqa- tso tawm cov qauv thiab kev npaj ua ke (sib txuas nrog lwm cov tshuaj tiv thaiv kab mob) kom ntev tshuaj ib nrab- lub neej thiab txhim kho kev kho mob kom zoo.
Ntxiv dag zogNtau lub tuam txhab tau ua cov kev tshawb fawb soj ntsuam ntawm 250mg lub zog qis kom hloov mus rau cov neeg mob uas muaj qhov sib txawv ntawm lub cev hnyav thiab txo cov nqi tshuaj.
