Indapamide Ntsej Muag

Indapamide ntsiav tshuaj, cov khoom tseem ceeb yog indapamide, uas yog sulfonamide derivative nrog ob qho diuretic thiab calcium antagonist cov khoom.

Lub npe siv tshuaj 【
Cov Npe Generic: Indapamide Ntsej Muag
English lub npe: indapamide ntsiav tshuaj
【Cov Khoom xyaw】Cov khoom tseem ceeb: indapamide
Cov Khoom Siv Ntxiv: Pob kws partch, xiav qab zib, sodium carboxymethyl hmoov, zaj duab xis {{0} soluble).
Chemical Name: N-(2-Methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoyl-4-chlorobenzamide
Molecular cov mis: c16h16Cln3o3s
Molecular hnyav: 365.83
Profarser 【НIb zaj duab xis coated ntsiav tshuaj, uas pom dawb tom qab tshem tawm cov txheej.
【Kev qhia】Cov kev kub siab tshaj.
【Qhov Kev Tshawb Xyuas】2.5mg.
【Kev Pab Siv thiab Kev Siv Ntau】Siv lub siab, 1 ntsiav tshuaj ib 24 teev, nyiam dua thaum sawv ntxov. (Nce koob tshuaj tsis txhim kho cov antihypertive cuam tshuam ntawm indapamide, tab sis tsuas yog nce sab- cov txiaj ntsig.)
Cov nyom tshwm sim】
Cov ntsiab lus ntawm kev ruaj ntseg nta
Cov tshuaj tiv thaiv feem ntau yog qhov tsis txaus siab yog qhov sib xws (feem ntau tshwm sim rau cov tawv nqaij), uas feem ntau tshwm sim rau cov neeg mob tsis haum, cov kev ua xua los yog cov pob papular. Thaum lub sij hawm kuaj mob kev sim kev sim, tom qab 4 txog 6 lub lim tiam ntawm kev kho, hypokalemia (qib siab, qib ntshav siab yog <3.4 mmol / l. Tom qab 12 lub lis piam ntawm kev kho mob, qhov nruab nrab txo qis hauv cov ntshav poov tshuaj yog 0.41 mmol / l.
Feem ntau ntawm cov kev tshawb nrhiav thiab cov kev sib raug zoo uas muaj kev cuam tshuam tau koob tshuaj lom zem heev - nyob.
Ntsiab lus ntawm cov kev tshwm sim uas tsis zoo nyob rau hauv daim ntawv
Cov kev sib raug zoo hauv qab no tau pom thaum lub sijhawm kho nrog indapamide thiab yog qeb raws li cov ntu ntu hauv qab no:
Ntau heev (ntau dua los yog sib npaug rau 1/10); Ntau (ntau dua los yog sib npaug rau 1/100 rau<1/10); Uncommon (≥1/1000 to <1/100); Rare (≥1/10,000 to <1/1000); Very rare (≥1/100,000 to <1/10,000), Unknown (cannot be estimated from the available data).

【Contraindications 【
● Kev ua kom zoo rau cov khoom siv nquag, lwm yam sulfonamides, lossis ib qho ntawm kev khaws cia.
Ua tsis ua lub raum loj heev.
● Hepatic encephanathy lossis mob siab ua haujlwm tsis taus.
Hyphokalemia.
Cov khoom lag luam no feem ntau tsis pom zoo kom siv tau ua ke nrog cov tshuaj lom thiab tsis muaj tshuaj lom neeg uas tuaj yeem ua rau Torsiares tsib taw tes (saib [yeeb tshuaj sib cuam tshuam]).

【Cov kev ceev faj】
Lus ceeb toom
Thaum lub siab ua haujlwm tsis txaus ntseeg, thiazide -}}}}}}} ecection encephatopathy, tshwj xeeb tshaj yog nyob rau hauv muaj cov electrolyte disster. Yog tias qhov no tshwm sim, kev siv diuretics yuav tsum nres tam sim ntawd.
Kev yees duab
Muaj tau tshaj tawm cov teeb meem ntawm cov duab hauv cov neeg mob uas siv thiazides thiab thiazide {{}}}} ecerse recease]). Yog tias muaj kev tawm tsam photosensivity tshwm sim thaum lub sijhawm kho, nws raug nquahu kom tsis txhob ua yeeb yaj kiab. Yog tias diuretic yuav tsum tau siv dua, nws raug nquahu kom tiv thaiv thaj chaw uas raug tshav ntuj lossis cua dub.
Cov kev ceev faj
Dej thiab Kev Ntsuas Hluav Taws Xob
Tshuaj sodium
Ntshav dej qab zib yuav tsum tau ntsuas ua ntej kev kho mob, thiab tom qab ntawd saib xyuas tsis tu ncua. Ib qho kev txo qis hauv cov sodium tej zaum yuav yog asymptomatic thaum xub thawj, yog li kev saib xyuas ntawm cov sodium yog qhov tseem ceeb. Nyob rau hauv high - kev pheej hmoo ntawm cov neeg laus thiab cov neeg mob uas tau saib xyuas yuav tsum tau ntau dua (saib [muaj kev txom nyem] thiab noj ntau dhau]). Txhua yam kev ua diuretic kev kho mob yuav ua rau muaj kev mob siab, qee zaum nrog kev rau txim loj heev. Hyponatremia nrog hypovolemia yuav ua rau lub cev qhuav dej thiab orthostatic hypotension. Kev sib xyaw ua ke ntawm cov poov tshuaj ES tej zaum yuav ua rau theem nrab cov metabolic alkalosis; Qhov tshwm sim ntawm cov nyhuv no yog tsawg thiab qib yog qhov me me.
Dej Ntshav Qab Zib
Cov poov tshuaj poob thiab hypokalemia yog cov kev pheej hmoo loj los ntawm thiazides thiab lwm yam diuretics. Rau qee qhov siab -}} Cov neeg mob thiab / lossis siv ntau yam tshuaj, cov neeg mob uas muaj lub plawv plawv thiab mob plawv, thiab lwm yam kev pheej hmoo ntawm hypokalemia (<3.4 mmol/L) must be prevented. Because in these situations, hypokalemia increases the cardiotoxicity of digitalis preparations and the risk of arrhythmias.
Cov neeg mob uas muaj lub sijhawm ntev tshaj plaws ntawm Electrocardiogram, txawm tias koj rov qab los yog iatrogenic, yog ntawm qee qhov kev pheej hmoo thaum siv cov tshuaj no. Hypokalemia (thiab Bradycardia) yog ob qho tib si uas tuaj yeem ua rau muaj kev ua kom hnyav hnyav
Tag nrho cov ntawm cov xwm txheej saum toj saud yuav tsum tau saib xyuas cov ntshav cov ntshav.
Kev ntsuas kev ntsuas ntawm cov ntshav yuav tsum tau txais hauv thawj lub lim tiam tom qab pib cov tshuaj.
Hypokalemia yuav tsum tau kho ib zaug kuaj pom.
Tshuaj calce calcium
Thiazides thiab lwm yam diuretics tuaj yeem txo tso zis tso zis ntxiv, ua rau muaj kev nce qib me ntsis thiab kev hloov pauv ntawm cov qib ntshav calcium. Ib qho kev ua ntshav muaj txiaj ntsig tseem ceeb nyob rau hauv cov ntshav calcium yuav tshwm sim los ntawm yav tas los tsis tau lees paub hyperparathyroidism. Kev kho mob yuav tsum raug tso tseg ua ntej tshawb xyuas qhov ua haujlwm ntawm parathyroid muaj nuj nqi.
Ntshav qab zib
Cov neeg mob ntshav qab zib yuav tsum tau them nyiaj rau kev saib xyuas cov ntshav cov ntshav qab zib, tshwj xeeb tshaj yog thaum hypokalemia tshwm sim.
Uric acid
Hauv cov neeg mob uas muaj cov tshuaj hyperuricemia, kev siv tshuaj no yuav nce qhov tshwm sim ntawm gout kev.
Kev sib txheeb ntawm lub raum muaj nuj nqi thiab kev ua tau zoo ntawm diuretics
Thiazides thiab lawv cov kev cuam tshuam ntawm diuretics tsuas yog siv zog tag nrho thaum lub sij hawm hloov dua siab tshiab yog tsawg dua 25 mg / dL, uas yog, 220 μmol / l). Rau cov neeg laus, cov txuj ci ci yuav tsum tau hloov kho raws li lub hnub nyoog, qhov hnyav, thiab tub los ntxhais.
Nyob rau hauv thawj theem ntawm kev kho diuretic, vim yog poob dej thiab sodium, uas yuav ua rau muaj kev tiv thaiv cov ntshav ntawm urea thiab creatinine hauv cov ntshav. Qhov kev pab cuam lub raum tsis txaus ntseeg tsis ua rau cov neeg mob qub uas suav tias yuav ua haujlwm ntxiv ntawm pre- lub raum ntxiv tsis txaus.
Ncaws pob
Cov neeg ncaws pob yuav tsum nco ntsoov tias cov khoom xyaw nquag muaj nyob hauv cov tshuaj no tej zaum yuav muab qhov txiaj ntsig zoo hauv kev sim siv doping. Cov neeg ncaws pob yuav tsum siv nws nrog ceev faj.
Nyhuv rau lub peev xwm tsav thiab khiav lag luam machinery
Cov khoom no tsis cuam tshuam kev ntxhov siab, tab sis nyob rau hauv tus kheej cov kev sib txawv ntsig txog kev kho ntshav siab yuav tshwm sim, tshwj xeeb thaum pib kev kho mob lossis thaum ntxiv lwm cov tshuaj antihizer.
Yog li ntawd, lub peev xwm los tsav tsheb lossis tsav cov tshuab yuav tsis muaj zog.
【Siv rau cev xeeb tub thiab lactating poj niam】
Sij hawm xeeb tub
Muaj cov ntaub ntawv txwv ntawm kev siv ntawm indapamide rau cov poj niam cev xeeb tub (tsawg dua 300 cev xeeb tub tau txais txiaj ntsig). Ntev -}} Todle raug rau Thiazides nyob rau hauv lub caij ntshav ntshav siav, uas yuav ua rau mob plab me me tuaj yeem ua rau mob plab mog tuaj yeem ua rau mob plab mog tuaj yeem ua rau mob plab mog tuaj yeem txo cov ntshav plab. Cov kev tshawb fawb tsiaj tsis tau qhia ncaj qha lossis tsis txaus ntseeg ua rau muaj kev phom sij ntawm kev ua me nyuam sib deev lom zem (saib [chaw muag tshuaj]).
Raws li kev ceev faj, nws yog qhov zoo tshaj plaws kom tsis txhob siv indapamide thaum cev xeeb tub. Cov tshuaj zoo li no yuav tsum tsis txhob siv los kho kev tiv thaiv kev tiv thaiv kev tiv thaiv kev tiv thaiv kev xeeb tub.
Lactation
Muaj cov ntaub ntawv tsis txaus ntawm lub zais ntawm indapamide / metabolites nyob rau hauv tib neeg cov mis nyuj. Tej zaum yuav muaj kev ua xua rau sulfonamide - derived tshuaj thiab hypokalemia. Kev pheej hmoo rau tus menyuam mos / menyuam mos tsis tuaj yeem raug cais tawm.
Indapamide yog qhov zoo sib xws rau koj sab nraud, thiab tom kawg yog txuam nrog ib qho kev txo qis hauv lactation thaum pub mis niam.
Indapamide yuav tsum tsis txhob siv thaum pub niam mis.
Kev muaj peev xwm
Kev ua me nyuam Toxicity kev tshawb fawb tau qhia tsis muaj qhov cuam tshuam ntawm kev muaj peev xwm ntawm txiv neej thiab poj niam nas (saib [chaw muag tshuaj thiab toxicology]. Nws cia siab tias yuav tsis muaj kev cuam tshuam rau tib neeg fertility.
【Siv rau cov menyuam】
Kev nyab xeeb thiab ua hauj lwm zoo ntawm cov tshuaj no hauv menyuam yaus tsis tau txiav txim siab.
【Siv hauv cov laus】
Saib cov ntsiab lus hauv lwm ntu, lossis ua raws li kws kho mob cov lus qhia.
【Tshuaj sib cuam tshuam】
Tsis muaj cai ua ke
Lithium
Hauv qhov qis -}}}}}} kev noj haus ntawm Lithium hauv cov zis thiab ua kom pom kev ntawm cov lithium ntau dhau. Txawm li cas los xij, yog tias txoj kev diuretic yuav tsum siv, cov qib ntshav lithium yuav tsum yog saib xyuas kom zoo, thiab cov tshuaj yuav tsum tau hloov kho raws li xav tau.
Kev kho kom haum uas xav tau kev saib xyuas.
Cov tshuaj uas ua rau Torsades tsib taw tes.
● Chav Kawm Ia Antiarrhythmic tshuaj (Quinidine, Hydroquinidine, DisopyrYramide).
● Chav kawm ntawv IIli Antiarrhythmic (feodarone, sotalol, dofetilide, ibutilide).
Qee cov tshuaj tiv thaiv kab mob Antipsychhot:
● Phenothiazines (Chlorpromazine, Cyamemazine, Levaspromazine, Thiorgenazine, Trifluopterazine).
● Benzamides (amisulpride, sulpiride, sulpiride, sulpiride, tiapride).
● Butyrohenones (haloperidol).
Lwm tus: Brepridil, ciscridil, dibenmanin IV, hayfromycin, pentamidine, moxifloxacin, vincamine IV.
Txoj kev pheej hmoo ntawm ventricular arhythmias, tshwj xeeb tshaj yog torsquat de taw, yog nce (hypokalemia yog qhov pheej hmoo ua ke).
Ua ntej qhia txog kev sib txuas ua ke, saib xyuas rau hypokalemia thiab kho nws raws li xav tau. Cais tshuaj, Plasma Electrolyte, thiab Electrocardiogram soj ntsuam.
Thaum hypokalemia yog tam sim no, siv cov tshuaj uas tsis muaj lub drawback ntawm inducing torsades tsib taw.
Tsis - steroidal anti {{
Tej zaum yuav txo cov txiaj ntsig antihypertensive ntawm indapamide.
Nws muaj kev pheej hmoo ntawm lub raum tsis ua hauj lwm (txo cov lus qhia glomerular) nyob rau hauv cov neeg mob qhuav dej.
Tus neeg mob yuav tsum yog hydrated, thiab lub neej muaj zog uas yuav tsum tau saib xyuas txij thaum pib kho.
Angiotensin -} hloov enzyme (ace) inhibitors
Nyob rau hauv lub xub ntiag ntawm pre - kev pheej hmoo sodium tsis tau, muaj kev pheej hmoo ntawm kev ua tsis tiav thaum ua ke nrog cov neeg mob raum tsis sib thooj). Yog li ntawd, rau cov neeg mob uas muaj mob ntshav qab zib uas muaj sodium depetion vim tias kev saib xyuas dhau los, yuav tsum tau them rau:
● Ace Inibitors yuav tsum tau pib peb hnub tom qab cheem diuretic, thiab yog tias tsim nyog, lub poov tshuaj {}} excreting diuretic tuaj yeem rov pib dua.
● Los yog pib noj cov ace inhibitors ntawm qhov tshuaj qis thiab nce ntxiv noj kom maj mam.
Rau cov neeg mob uas muaj lub plawv dhia ua tsis tiav, tom qab txo cov tshuaj pleev ib ce ntawm poov tshuaj {}} kev kho mob ntawm diuretics, pib kho nrog ib koob tshuaj tivthaiv tsawg heev ntawm Ace inibitors.
Rau txhua tus neeg mob noj ACE inhibitors, raum muaj nuj nqi (senum creatinine cov ntsiab lus) yuav tsum tau sim nyob rau hauv thawj ob peb lub lis piam ntawm kev tswj hwm.
Lwm cov tebchaw uas ua rau muaj kev tiv thaiv hypokalemia
Ua kom cov kev pheej hmoo ntawm hypokalemia (cov nyhuv ntxiv).
Saib xyuas cov poov tshuaj cov ntsiab lus hauv cov ntshav thiab kho cov ntshav thiab kho thaum tsim nyog; Xav paub ntau ntxiv yuav tsum tau them thaum ua ke nrog kev npaj digitalis. Siv tsis -} stimulant cov tshuaj yaj.
Baclofen
Nce cov nyhuv antihypertensive. ReHydrate tus neeg mob; saib xyuas lub neej ntawm lub raum ntawm kev pib kho.
Digitalis npaj
Hypokalemia yog nquag rau ntxias cov tshuaj lom ntawm cov tshuaj digitalis. Saib xyuas yuav tsum tau them los soj ntsuam cov ntshav cov poov tshuaj thiab electrocardiogram, thiab kev kho yuav tsum tau rov ua yog tias tsim nyog.
Allopurinol:
Thaum siv hauv kev sib xyaw nrog indapamide, nws tuaj yeem nce qhov tshwm sim ntawm Allopurinol hypersensitivity.
Kev txiav txim siab rau kev kho mob
Poov tshuaj - sparing diuretics (amiloride, spironolactone, triamterene)
Qhov tsim nyog ua ke tau txais txiaj ntsig zoo rau qee cov neeg mob, tab sis hypokalemia lossis hypokalemia tseem muaj tshwm sim (tshwj xeeb hauv cov neeg mob uas muaj ntshav qab zib thiab ntshav qab zib). Cov xim yuav tsum tau them los soj ntsuam cov poov tshuaj cov ntsiab lus hauv cov ntshav thiab electrocardiogram, thiab kev kho mob yuav tsum tau rov kawm yog tias tsim nyog.
Tus metformin
Lub Renal Renal tsis ua tiav uas yuav raug ntxias los ntawm diuretics (suav nrog lub voj Diuretics) tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tshuaj hnyuv tshuaj hnyuv acidosin.
Metformin yuav tsum tsis txhob siv thaum cov ntshav ntshiab creatinine qib ntau dua 15 mg / l (135 μmol / l) thiab nyob rau hauv cov poj niam ntau dua 12 mg / l (110 μmol / l).
Iodinated sib piv Media
Rau cov neeg mob uas muaj lub cev qhuav dej vim kev siv ntawm diuretics, kev sib xyaw ua ke ntawm cov kev pheej hmoo ntawm lub raum tsis ua hauj lwm, thiab kev pheej hmoo yog ntau dua nrog high {di dose iodinated piv media.
Tus neeg mob yuav tsum tau rov qab ua ntej siv iodine compounds.
Imipramine -} Hom tshuaj tiv thaiv kev ntxhov siab (Trricycucceptics), Neuroleptics
Txhim kho cov nyhuv antihypertive thiab tseem yuav ua rau muaj kev pheej hmoo ntawm orthostatic hypotension (additive nyhom).
Calcium (ntsev)
Ua kom muaj kev pheej hmoo ntawm hypercalcemia vim raug txo tso zis tso zis ntau tshaj tawm.
Cyclosporine, Tacrolimus
Muaj kev pheej hmoo ntawm cov dej hiav txwv uas tsis muaj nce qib zuj zus ntawm Cyclosporine hauv cov kev ncig thiab txawm tias tsis muaj dej / sodium depetion.
Corticosteroids, tetracosactide (systemic)
Txo cov nyhuv antihypertive ntawm indapamide (vim dej / sodium returent tshwm sim los ntawm corticosteroids).
【Overuced】
Tsos mob
Tsis muaj tshuaj lom tau pom txawm tias thaum indapamide tau siv txog 40 mg. Qhov no yog 16 lub sij hawm cov koob tshuaj uas kho tau.
Toxicity Toxicity feem ntau yog manifested li dej / electrolyte dissiders (hyponatremia, hypokalemia). Cov chaw kho mob yog xeev siab, ntuav, kev mob siab, qaug zog, tsis meej pem lossis oliguria lossis anuria (los ntawm cov ntshav ntim).
Kev kho
Thawj txoj kev kho mob tau hais nyob rau hauv ib lub chaw kho mob tshwj xeeb yog: tshem tawm cov tshuaj tshwj xeeb kom sai li sai tau dhau los ntawm kev ua haujlwm mob plab thiab / lossis noj hluavtaws ua haujlwm. Tom qab ntawd, dej thiab electrolytes yuav tsum tau ntxiv los rov qab ua kom muaj kev sib npaug ntawm cov dej thiab elecolytes.
【Pharmacology thiab Toxicology】
Indapamide yog sulfonamide diuretic. Los ntawm inhibiting lub re -}}} pa tawm ntawm cov zis, nws tau nce cov zis tawm thiab ua rau cov mob antihyperensive thaum muaj kev lom zem me me.
【Pharmacokinetics】
Kev nqus
Indapamide muaj qhov siab Bioavailability (93%).
Tom qab noj cov tshuaj 2.5 mg, lub sijhawm kom ncav cuag cov ntshav ntshav siab (tmax) yog 1 mus rau 2 teev.
Kev faib
Tus nqi khi ntawm indapamide rau Plasma Proteins yog 75%.
Kev tshem tawm ib nrab - lub neej yog 14 - 24} sijhawm (nrog ib nrab ntawm 18 teev).
Piv nrog ib qho - Dose Adasument, tus khov kho {{{1} {yog siab dua nrog kev siv tshuaj txhuam hniav ntau dua, thiab cov toj siab tseem nyob ruaj khov tsis muaj kev sib tw.
Ua kom loj
Renal Clearance account rau 60% - 80}% ntawm tag nrho cov kev tshem tawm.
Tus nqi ntawm cov yeeb tshuaj tau tawm hauv cov zis yam tsis muaj Metabolized yog 5%. Feem ntau ntawm indapamide tau tawm ntawm lub cev hauv daim ntawv ntawm cov metabolites.
Lub raum tsis ua hauj lwm
Rau cov neeg mob uas muaj raum tsis ua tiav, qhov kawg -}} hais cov tshuaj papaceters nyob tsis hloov.
【Cia】 Tiv thaiv los ntawm lub teeb thiab khaws cia hauv cov thawv ntim khoom.
PLY pob】 Muaj tshuaj tua hluav taws xob thiab cov tshuaj txhuas {}}}}}}}}}}} Kev ntim khoom ntim rau 10 lub ntsej muag ib lub thawv; 10 cov ntsiav tshuaj ib lub hlwv, 3 tus hlwv rau ib lub thawv.
【Txee - lub neej】 36 lub hlis
Cov Qauv Kawm Ntawv 【Kawm Ntawv Sau Npe Tshuaj Rau Cov Kws Kho Mob Hauv Tebchaws YBB01752023
Won 【Kev Pom Zoo】 Gualoao Zhunzi H19994074