Nifedipine ntsiav tshuaj

Nifedipine ntsiav tshuaj. Cov lus txhais: Adalat, Commardia, thiab lwm yam .Qhov kev taw qhia muaj raws li nram no: 1.angina pectoris: varidont artoris; tsis muaj vaj ntxwv istable anga-pectoris; Mob Aponic ruaj khov angina pectoris.2.

Tawg (siv ib leeg lossis sib xyaw ua ke nrog lwm cov tshuaj antihyperensive).

Lub npe siv tshuaj 【
Cov Npe Generic: Nifedipine ntsiav tshuaj
English Lub Npe: Nifedipine ntsiav tshuaj
【Cov Khoom xyaw】Nifedipine
Siv Lub Npe: 2,6-Dadethyl-4 (2-nitrophenyl) -1,4-wsdro-3,5-Pyridinedicarboxylic Acid Dutrethyl Ester
Molecular cov mis: c17h18n2o6
Molecular hnyav: 346.34
【Tsos】Ib zaj duab xis coated ntsiav tshuaj, uas zoo li daj tom qab tshem tawm cov txheej.
【Kev qhia】1. Lub angina pectoris: varidt angina pectoris pector; Tsis muaj vaj ntxwv istable anga-pectoris; Mob Aponic ruaj khov angina.
2. Ntshav siab (ib leeg lossis sib xyaw ua ke nrog lwm cov tshuaj antihyperensive).
【【Specification】 5mg.

【Kev Pab Siv thiab Kev Siv Ntau】
1. Qhov ntau npaum ntawm nifedipine yuav tsum tau hloov maj mam kho raws li tus neeg mob lub siab thiab tswj ntawm Angina pectoris. Overdosing ntawm nifedipine tuaj yeem ua rau ntshav siab.
2. Pib noj ntawm ib qho koob tshuaj me, feem ntau pib ntawm 10mg / sijhawm (2 ntsiav tshuaj ib zaug), hais lus rau ib hnub twg; Cov tshuaj kho ib txwm siv yog 10-20mg / Time orally (2-4 ntsiav tshuaj ib zaug), 3 zaug ib hnub. Rau cov neeg mob uas muaj kev sib koom tes zoo nkauj, nws tuaj yeem siv tau li 20-30mg / sijhawm (4-6sets ib zaug), 3-4 zaug ib hnub. Qhov ntau tshaj koob yuav tsum tsis pub tshaj 120mg / hnub (24 ntsiav tshuaj (24 ntsiav tshuaj ib hnub). Yog hais tias tus mob yog maj nrawm, nws tuaj yeem tau zom thiab noj kom zoo lossis tshem tawm ntawm cov koob tshuaj 10mg / sijhawm (2 ntsiav tshuaj ib zaug). Nyob ntawm tus neeg mob teb rau cov tshuaj, nws tuaj yeem txiav txim siab los tswj hwm nws dua.
3. Feem ntau, kho cov nqi siv 7-14 hnub. Yog tias tus neeg mob cov tsos mob muaj qhov pom tseeb thiab qhov mob sai, lub sijhawm hloov kho lub sijhawm tuaj yeem ua kom luv. Raws li tus neeg mob teb rau cov tshuaj noj, zaus ntawm kev tawm tsam, thiab noj tshuaj) mus rau 30mg / sijhawm (6 ntsiav tshuaj nyob rau lub sijhawm) tsis pub dhau 3 hnub.
4. Rau cov neeg mob tsev kho mob raws li kev soj ntsuam nruj, 10 ntsiav tshuaj (2 ntsiav tshuaj) tuaj yeem ntxiv txhua 4-6 teev raws kev tswj hwm ntawm angina lossis ischemic arrhythmia.
Cov nyom tshwm sim】

1. Ib qho tshwm sim ntawm Peripheral Edema tom qab noj tshuaj (peripheral edema yog noj li ntawm 4% thaum noj 600mg / hnub); Qeej taub hau, mob taub hau, qias neeg, nkees thiab ntsej muag yaug (10%). Hloov pauv hypotension (5%), feem ntau tsis tas yuav tsum tau ua kom tsis txhob muaj tshuaj (hloov chaw ntawm 2mg / hnub thiab 5% ntawm kev txhaj tshuaj ntawm 120mg / hnub). Cov neeg mob yuav muaj kev tawm tsam angina, uas yuav cuam tshuam nrog cov kev xav tsis zoo. Palpitations, Nasal congestion, lub hauv siab nruj, mob nqaij hlav, mob plab, mob plab zom mov, nqaij daim tawv, thiab kab mob plab, thiab lwm yam (2%). Xaub-(0.5%), yuav tsis muaj tshwm sim yog txo qis lossis ua ke nrog lwm cov tshuaj anti anti anti anti siv yeeb tshuaj.
2. Tsis tshua muaj ntshav, txo cov ntshav siab, tsis pom kev phem, tsis txaus ntseeg, tsis txaus ntseeg, tsis txaus ntseeg, tiv thaiv tsis tau mob caj dab, thiab lwm yam (0.5%).
3. Tej yam kev nyuaj siab loj: Qhov tshwm sim ntawm myocardial infarction thiab lub plawv tsis ua hauj lwm yog 4%; Qhov tshwm sim ntawm pulmonary Edema yog 2%; Qhov tshwm sim ntawm Arrhythmia thiab conduction block yog tsawg dua 0.5% txhua.
4. Cov khoom siv rau cov khoom no tuaj yeem tsim kho tus kab mob siab tsis haum, pob xoo, thiab txawm tias muaj mob dermatitis.
【Contraindication song 【【Nws yog contraindicated rau cov tib neeg ua xua rau nifedipine.

【Cov kev ceev faj】
1.Thypotension: Feem ntau cov neeg mob uas muaj ntshav siab tsuas yog muaj mob qog me tom qab noj nifedipine, thiab ob peb tus neeg mob yuav txaus siab rau cov mob hypotenses. Qhov kev tawm tsam no feem ntau tshwm sim thaum lub sij hawm hloov kho lossis noj ntau ntxiv, tshwj xeeb tshaj yog thaum ua ke nrog beta blockers. Nyob rau lub sijhawm no, cov ntshav siab yuav tsum tau raug saib xyuas, tshwj xeeb tshaj yog thaum ua ke nrog lwm cov tshuaj antihyperensive.
2.Pi ascients tab niam Txoj Hmoo leeg hla kev hla kev (lossis lwm yam kev phais mob hauv Fentanesl) Yog tias muaj kev kawm pom zoo, cov tshuaj yuav tsum tau txiav kom tsawg kawg 36 teev.
3. Guarina thiab / lossis myocardial infarction: tsawg heev ntawm cov neeg mob sib txawv, ua rau lub plawv dhia dawb, ua rau muaj kev nce siab ntxiv ntawm angina lossis morocardial infarction.
4.peripalal Edema: 10% ntawm cov neeg mob sib deev me me rau nruab nrab peripheral edema, uas muaj feem cuam tshuam rau arterial dilation. Edema feem ntau yog thawj zaug tshwm sim hauv qab nqua thiab tuaj yeem kho nrog diuretics. Rau cov neeg mob uas muaj lub plawv dhia tsis ua haujlwm, nws yog ib qhov tsim nyog kom paub qhov txawv txawm edema yog tshwm sim los ntawm kev puas tsuaj ntxiv ntawm sab laug ventricular muaj nuj nqi.
5.symptoms ntawm "Rebound" ntawm Beta Blockers: Suds dispontining ntawm beta blockers thiab siv nifedipine, tej zaum yuav ua rau anga pectoris. Qhov ntau npaum li cas ntawm cov qub yuav tsum maj mam txo.
6.Cove lub plawv tsis ua haujlwm: tus naj npawb me me uas tau txais nifedipine, thiab cov neeg mob uas tsis muaj qhov phom sij loj yog qhov muaj feem ntau muaj feem ntau.
7.Txhua qhov kev kuaj mob: Siv cov khoom lag luam no, tej zaum yuav nce hauv Alkaline Phosphatase, Aspartate Dhydransferase, thiab Alanine AminotRanserase. Feem ntau, tsis muaj cov tshuaj hauv cov tsos mob, tab sis muaj tau tshaj tawm tias Bile Stasis thiab Jaundice; tsawg zuj zus kev sib sau los ntshav thiab lub sijhawm los ntshav ntev; Kuaj ncaj qha rau / tsis muaj hemolytic anemia.
8.Patients nrog daim siab thiab lub raum tsis txaus ntseeg yuav tsum ceevfaj thiab pib nrog kev mob me me los tiv thaiv kev mob siab rau ntawm angina, lub plawv tsis ua haujlwm, thiab txawm tias myocardial infarction. Cov neeg mob uas muaj lub raum sawv rov qab yuav tsis muaj peev xwm nce ntshav urea nitrogen thiab creation thaum siv cov khoom no, thiab kev sib raug zoo nrog nifedipine tsis meej txaus.
9.Txoj kev tswj hwm lub sijhawm yuav tsum tsis txhob raug ntes sai sai kom tsis txhob tshwm sim kom zam dhau qhov tshwm sim ntawm kev tshem tawm syndrome thiab rov qab.
【Menyuam thiab lactating poj niam】
1. Tsis muaj cov ntaub ntawv tshawb fawb ntxaws ntxaws cov ntaub ntawv tshawb fawb. Cov kev sim tsiaj tau pom tias nifedipine muaj cov nyhuv teratogenic rau embryos, tab sis tsis muaj kev tshaj tawm tib neeg.
2. Nifedipine tuaj yeem zais rau hauv niam mis. Breast-feeding women should either stop taking the drug or stop breast-feeding.
【Cov Me Nyuam】Tsis meej.
【Cov neeg mob laus】Lub ib nrab - lub neej ntawm nifedipine yog ntev nyob rau hauv cov laus, yog li saib xyuas yuav tsum tau them rau kev kho cov nqi thaum nws thov.
【Tshuaj sib cuam tshuam】
1.Nws: thaum ua ke nrog cov khoom no, nws tuaj yeem tswj qhov pib ntawm angina pectoris thiab muaj kev thev taus zoo.
{{02. - blockers: kev sib xyaw ua ke nrog cov khoom no nrog} blockers zoo- bagivated thiab zoo hauv feem coob ntawm cov neeg mob. Txawm li cas los xij, hauv qee tus neeg mob, nws yuav ntxias thiab ua rau mob siab tsis zoo, lub plawv tsis ua haujlwm, thiab angoris pectoris.
3.Digitalis: Cov khoom no yuav nce cov digoxin kev xav tau. Nws raug nquahu kom saib xyuas cov ntshav digoxin concentration thaum pib siv, kho cov ntshav ntawm digoxin thaum ua tsis tiav cov khoom no.
4.When siv cov tshuaj uas muaj cov protein ntau- Cov tuab neeg siv, quinium, quinium, warfarin, thiab lwm yam. Hloov pauv.
5.Txoj keetidine siv ua ke nrog cov khoom no, lub plasma ncov siab ntawm cov khoom no nce ntxiv. Saib xyuas yuav tsum tau them los kho qhov ntau npaum li cas.
6. Cov neeg mob tab tom sib koom ua ke ntawm txoj kab mob caj qaum (los yog lwm yam kev phais mob hauv Fentants Yog tias muaj kev kawm pom zoo, cov tshuaj yuav tsum tau txiav kom tsawg kawg 36 teev.
【Pharmacology thiab Toxicology】 Nifedipine yog Dihydropyridine Artium. Nws tuaj yeem xaiv tau tiv thaiv lub tsheb thauj khoom ntawm cov calcium ions rau hauv myocardial cells thiab inroocit cov calcium thiab inhibit cov kab mob calcium yam tsis muaj hloov ntshav ntshav calma ion.
1. Cov chaw muag tshuaj
(1) Cov khoom lag luam no tau ua ke ib txhij nrog cov hlab ntsha hauv ob qho tib si ntawm cov leeg ntshav plab, thiab ua kom cov leeg ntshav plab.
(2) Cov khoom no tuaj yeem cuam tshuam myocardial consaction, txo cov myocardial metabolism, thiab txo qis myocardial oxygen noj.
(3) Cov khoom no tuaj yeem ua rau cov nkoj ua hauj lwm ntev, txo cov ntshav siab thiab txo cov ntshav siab thiab daws tau cov ntshav hauv lub siab.
(4) Cov khoom no tuaj yeem ncua kev ua haujlwm ntawm lub sino-}}} kev daws teeb meem ntawm lub plawv sib cais; Electrophys cov kev kawm txog cov tsiaj thiab tib neeg tsis pom muaj kev ncua ntawm lub sijhawm thiab lub sijhawm ntev}}} Atrial ntawm tus nqi.
2. Toxicology
Tsis muaj cov nyhuv carcinogenic. Tsis muaj mutagenicity. High {{{2} Daim ntawv thov koob tshuaj no tuaj yeem txo cov fecundity ntawm cov poj niam nas; Nws tuaj yeem ua rau teratogenesis; Nws tuaj yeem ua rau rho menyuam tawm (tus nqi nqus tus nqi ntawm cov nas tsuag tau nce ntxiv, tus nqi tuag ntawm cov pob txha nce siab, thiab cov muaj sia nyob ntawm cov nas uas tsis muaj zog. Cev xeeb tub liab noj 2 / 3 - 2 lub sij hawm lub siab tshaj plaws tib neeg tuaj yeem ua rau kev loj hlob me me thiab tsis tiav; Tso cov nas 3 lub sij hawm tus neeg muaj koob tshuaj siab tshaj plaws tuaj yeem ua rau kev xeeb tub lub caij nyoog. Qhov cuam tshuam rau tib neeg fecundity tseem tsis meej.

【Pharmacokinetics】
Nws yog sai thiab txo kev nqus tau tom qab tswj qhov ncauj. Nws cov ntshav tshuaj muaj zog tuaj yeem pom tau 10 feeb tom qab kev tswj hwm qhov ncauj, thiab kev ua kom muaj ntshav noj ntshav tau txog 30 feeb tom qab. Lub sijhawm los mus txog lub ncov yog siab dua thaum cov tshuaj yog zom lossis ua kom txaj muag. Tsis muaj ib qho tseem ceeb sib txawv hauv Bioavailability thiab ib nrab- lub neej thaum lub koob tshuaj nifedipine yog nruab nrab ntawm {}} mg. Muaj qhov tsis muaj qhov sib txawv hauv tus txheeb ze bioavailability ntawm nqos, zom, thiab kev sib cais ntawm nifedualine ntsiav tshuaj. Nifedipine yog qhov ua tau zoo heev rau Plasma Proteins, kwv yees li 90%. Nws siv tau thaum 15 feeb tom qab kev tswj xyuas qhov ncauj, ncav cuag nws lub ncov nyhuv hauv1 - 2}4 - 8 sijhawm; Nws yuav siv sij hawm cuam tshuam {14 14}} feeb tom qab kev tswj hwm tshem tawm thiab ncav cuag lub ncov hauv 20 feeb. Lub T1 / 2 yog biphasic, nrog T1 / 2 tau2.5 - 3}} sijhawm thiab t1 / 2 yog 5 teev. Cov tshuaj tau hloov mus rau hauv cov metabolites nyob hauv daim siab, thiab kwv yees li 80% tau tawm los ntawm ob lub raum thiab 20% yog ua tiav nrog quav. Cov metabolism thiab ua kom zoo ntawm nifedipine yog txo nyob rau hauv cov neeg mob uas muaj siab ntsws thiab lub raum tsis txaus.
【Cia】Tiv thaiv los ntawm lub teeb thiab khw muag khoom hauv lub thawv ntim khoom.
【Pob】Ntawm qhov ncauj cov tshuaj, ntim rau hauv high - qhov ceev polyethylene raj, 100 ntsiav tshuaj ib lub raj mis.
【Siv tau】36 lub hlis.
【Tus Qauv】Ch.p {. 2020}, Tshooj II.
【Tshuaj Kev Pom Zoo】Gualoa Zhunzi H12020305